Inflammatory bowel disease attacks quickly and makes patients miserable. Recently, British researchers found the key factors causing inflammatory bowel disease. Now let's take a look at the key factors caused by inflammatory bowel disease!
Nedávno britský výskumný tím zistil, že proteín s názvom T-bet hrá dôležitú úlohu pri udržiavaní krehkej rovnováhy medzi črevným imunitným systémom a črevnou flórou. Experimenty ukazujú, že delécia tohto proteínu môže viesť k symptómom podobným ľudskej zápalovej chorobe čriev (IBD) u myší. Preto sa vedci domnievajú, že spôsob, akým proteín ovplyvňuje črevný imunitný systém, možno použiť ako smer výskumu a konečne pripraviť cestu pre vývoj nových metód na liečbu zápalových ochorení čriev. Príslušné výsledky výskumu boli uverejnené v online vydaní najnovšieho vydania Journal of immunology.
Inflammatory bowel disease refers to ulcerative colitis and Crohn's disease. This disease is common in western countries, and the prevalence rate in China has also begun to rise sharply in recent years. The etiology of inflammatory bowel disease is still unclear, but most studies have targeted the intestinal immune system. A large number of bacteria are parasitic in the human intestine, which plays an important role in maintaining human health. Under normal circumstances, the intestinal immune system will not respond to the activities of beneficial bacteria in the intestine, but only play a role when the internal balance is destroyed. The intestinal immune system of patients with inflammatory bowel disease is different. It will make an immune response to the beneficial flora in the intestine, leading to chronic inflammation.
In a research project funded by the British Medical Research Council and the Wellcome foundation, the research team led by Professor Graham Lord of King's College London found that a protein called T-bet has a strong influence on the interaction between cells of the intestinal immune system. The deletion of this protein will lead to the dysfunction of immune cells, cause inflammation and eventually lead to the occurrence of inflammatory bowel disease. Experiments have proved that once the T-bet protein in the mouse immune system is removed, it will lead to the symptoms similar to human inflammatory bowel disease in mice; Using these proteins as therapeutic targets can reverse the symptoms of inflammatory bowel disease in mice.
Vedci poukázali na to, že ich výskum má veľký význam pre potvrdenie imunitných buniek a molekulárnych procesov, ktoré môžu po prvýkrát viesť k zápalovému ochoreniu čriev; Vylepšenie proteínu T-bet
